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折扣/货期| 货号：25620 | 规格：50 µg | 目录价：￥6636 |
产品详情
产品名称:
RIG-I helicase domain (human, recombinant)
别名:
DEAD Box Protein 58|Probable ATP-dependent RNA Helicase DDX58|Retinoic Acid-inducible Gene 1 Protein
产品描述:
Retinoic acid-inducible gene I (RIG-I), also known as DDX58, is a cytosolic DExD/H-box RNA helicase and an immune sensing receptor encoded by DDX58 in humans.{48287} It is composed of a C-terminal repressor domain, a central RNA helicase domain, and two N-terminal caspase recruitment domains (CARDs).{48287,48288} Following recognition of viral dsRNA by the C-terminal and helicase domains, the helicase domain induces an ATP-dependent conformational change, allowing for interaction of the CARD domains with mitochondrial antiviral-signaling protein (MAVS) and induction of a type I interferon (IFN) response.{48287,48288,48289} A single amino acid substitution of phenylalanine for cysteine at position 268 in the RIG-I helicase domain (RIG-IC268F) leads to enhanced NF-κB activity and expression of IFN-β in basal and poly (I:C)-stimulated cells.{48290} Overexpression of RIG-IC268F in human trabecular meshwork (HTM) cells induces cell death and is positively correlated with glaucoma, a core symptom in the type I interferonopathy atypical Singleton-Merten syndrome.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥80% estimated by SDS-PAGE
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