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折扣/货期| 货号：36890-1 mg | 规格：1 mg | 目录价：￥2926 |
| 货号：36890-10 mg | 规格：10 mg | 目录价：￥16100 |
| 货号：36890-5 mg | 规格：5 mg | 目录价：￥10248 |
产品详情
产品名称:
R 715 (trifluoroacetate salt)
别名:
[Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK|Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH
产品描述:
R 715 is a bradykinin B1 receptor antagonist.{67457} It inhibits contractions induced by bradykinin (Item No. 37408) in isolated human umbilical cords, which express bradykinin B1 receptors (pA2 = 8.49). R 715 (200, 400, and 600 µg/kg) decreases the latency to tail withdrawal in the tail-flick test in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; Item No. 13104).{67458} It reduces the incidence of hind limb weakness and paralysis, improves symmetrical gait, as well as decreases spinal inflammatory foci numbers, neuron demyelination, and lesion monocyte invasion, in a myelin oligodendrocyte glycoprotein (MOG) (35-55) (MOG35-55) antigen peptide-induced mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 1 mg/kg per day.{67459} R 715 (0.01 nmol/animal, i.c.v.) reduces mean arterial blood pressure and increases heart rate in spontaneously hypertensive rats.{67460}
保存温度:
-20
运输温度:
-20
预期分子量:
1140.3
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C57H81N13O12 • XCF3COOH
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