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    Isthmin-1 (mouse) (rec.)
    品牌: Adipogen
    产品货号: AG-40B-0215-C050
    规格: 50 ug

    报价:
    折后价:

    数量: - +
    产品详情
    * 以下信息仅供参考,详情请以原厂网站为准
    • 产品名称:
      Isthmin-1 (mouse) (rec.)
    • 别名:
      ISM1; ISM
    • 产品描述:
      Isthmin-1 (ISM1) was first identified as a gene expressed in the Xenopus midbrain hind brain organizer called isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Ism1 is an adipokine that induces glucose uptake in human and mouse adipocytes. Ism1 is secreted by mature adipocytes and triggers a signaling cascade similar to that of insulin, regulating glucose uptake while suppressing lipid accumulation. Recombinant Isthmin-1 or overexpression of Ism1 causes a robust increase in GLUT4-dependent glucose uptake in cultured primary murine and immortalized human adipocytes as well as in primary human muscle cells and prevents insulin resistance and hepatic steatosis in a diet-induced obesity mouse model. Ablation of Isthmin-1 causes glucose intolerance and impaired insulin-stimulated adipocyte glucose uptake. Isthmin-1 suppresses de novo lipogenesis and increases protein synthesis in hepatocytes whereas Isthmin-1 knockdown in adipocytes reduces glucose uptake and insulin-dependent phosphorylation of protein kinase AKT at serine residue 473 (p-AKTSer473). Isthmin-1 signaling is dependent on PI3K and shares downstream phosphorylation targets with insulin signaling, such as p-AKTSer473, p-AKTThr308, p-ERK1/2Thr202/Tyr204 and p-S6Ser235/236. Isthmin-1 does not seem to act through the insulin receptor or the insulin-like growth factor 1 receptor; it is most likely to signal through another, yet to be identified, receptor tyrosine kinase.
    • 反应种属:
    • 宿主来源:
      HEK 293 cells
    • 实验应用:
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    • 产品浓度:
      1mg/ml after reconstitution
    • 表达系统:
    • 阳性对照:
    • 保存温度:
      -20°C
    • 运输温度:
      BLUE ICE
    • 细胞定位:
    • 预期分子量:
      ~65kDa (SDS-PAGE)
    • 产品形式:
      solid
    • 存储溶液:
      Lyophilized. Contains PBS.
    • 有效期:
      Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
    • 产地:
      瑞士
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    • 样本类型:
      Lyophilized. Contains PBS.
    • 产品特点:
    • 纯度:
      >95% (SDS-PAGE)
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