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折扣/货期| 货号：13866 | 规格：50 µg | 目录价：￥6762 |
产品详情
产品名称:
PRMT6 (human recombinant; baculovirus expressed)
别名:
Histone Arginine N-methyltransferase PRMT6|HRMT1L6|Protein Arginine Methyltransferase 6
产品描述:
Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets.{20285,20245,20284} Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6.{20286} H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase.{20287} Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.{20284}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
有效期:
365
纯度:
≥60%
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