官网链接
折扣/货期| 货号：10007192 | 规格：1 ea | 目录价：￥1848 |
产品详情
产品名称:
PH Domain Leucine-rich Repeat Protein Phosphatase Blocking Peptide
别名:
KIAA0606 Protein|PHLPP|PLEKHE1 Protein|SCOP|Suprachiasmatic Nucleus Circadian Oscillatory Protein
产品描述:
To be used in conjunction with Cayman’s PHLPP polyclonal antibody (Catalog No. 10007191) to block protein-antibody complex formation during immunochemical analysis of PHLPP · Protein kinase B/Akt is critical in regulating cell growth and death. Phosphorylation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP dephosphorylates the hydrophobic motif of Akt and thus reduces Akt activity, resulting in a increase in the number of apoptotic cells.{13717} PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP into mice reduced tumor size by nearly 70% compared with control animals. mRNA of PHLPP is ubiquitously expressed, with highest levels found in brain.{13717}
保存温度:
-20
运输温度:
-20
产品形式:
200 µg of peptide in 200 µl TBS, pH 7.4, with 0.1% BSA and 0.02% sodium azide
有效期:
730
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