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折扣/货期| 货号：32061-1 mg | 规格：1 mg | 目录价：￥17208 |
| 货号：32061-100 µg | 规格：100 µg | 目录价：￥3132 |
产品详情
产品名称:
β-NGF (human, recombinant)
别名:
NGFβ|β-Nerve Growth Factor
产品描述:
β-Nerve growth factor (β-NGF) is a neurotrophin that is involved in the regulation of growth, proliferation, and survival of sympathetic and sensory neurons.{53786} NGF encodes pro-NGF that is composed of an N-terminal signal peptide and α-, γ-, and β-NGF domains. β-NGF, also known as mature or functional NGF, is produced after degradation of the signaling peptide and proteolytic cleavage of pro-NGF at Ser122.{53789,53787} β-NGF homodimerizes and induces neurotropic signaling through tropomyosin-related kinase A (TrkA) and the p75 neurotrophin receptor (p75NTR).{53787} β-NGF is produced by neurons in the cortex, pituitary gland, hippocampus, basal ganglia, thalamus, spinal cord, and retina, as well as in non-neuronal target cells of sympathetic and sensory neurons such as keratinocytes, vascular smooth muscle cells, exocrine salivary glands, and endocrine tissues.{53787,53788} Exogenous administration of β-NGF improves neurological deficits in murine models of traumatic brain injury (TBI), and β-NGF levels in the cerebrospinal fluid of TBI patients are positively correlated with neurological outcomes.{53787} Exogenous administration of β-NGF also accelerates the rate of skin excision wound healing in rats. Cayman’s β-NGF (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 118 amino acids and has a calculated molecular mass of 13.2 kDa.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 40 mM His, 40 mM Arg, pH 5.5, with 150 mM sodium chloride and 5% Trehalose, 5% Mannitol, 0.01% Tween-80
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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