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    BioXcell热销产品推荐--InVivoPlus anti-mouse PD-L1 (B7-H1)

    2023-04-27
    浏览次数: 137


    BioXcell热销产品推荐--InVivoPlus anti-mouse PD-L1 (B7-H1)


    产品描述:

    BioXcell InVivoPlus anti-mouse PD-L1 10F.9G2单克隆抗体与小鼠PD-L1(也称为B7-H1或CD274)反应。PD-L1是属于Ig超家族的B7家族的I型跨膜蛋白,分子量为40kDa。PD-L1在T淋巴细胞、B淋巴细胞、NK细胞、树突状细胞以及IFNγ刺激的单核细胞、上皮细胞和内皮细胞上表达。PD-L1与CD4和CD8胸腺细胞以及活化的T和B淋巴细胞和骨髓细胞上的受体PD-1结合。PD-L1与PD-1的结合导致抑制TCR介导的T细胞增殖和细胞因子产生。PD-L1被认为在肿瘤免疫逃逸中起着重要作用。诱导的PD-L1表达在许多肿瘤中很常见,并导致肿瘤细胞对CD8 T细胞介导的裂解的抗性增加。在黑色素瘤的小鼠模型中,可以通过用阻断PD-L1和PD-1之间相互作用的抗体进行治疗,暂时抑制肿瘤生长。10F.9G2抗体已被证明可以阻断PD-L1和PD-1之间以及PD-L1和B7-1之间的相互作用(CD80)。

    BioXcell热销产品推荐--InVivoPlus anti-mouse PD-L1 (B7-H1) 

    产品详情:

    产品名称

    InVivoPlus anti-mouse PD-L1 (B7-H1)

    产品货号

    BP0101

    产品规格

    5/25/50/100mg

    反应种属

    Mouse

    克隆号

    10F.9G2

    同种型

    Rat IgG2b, κ

    免疫原

    Mouse CD274

    实验应用

    in vivo PD-L1 blockade
    Immunofluorescence
    Immunohistochemistry (frozen)
    Flow cytometry
    Western blot

    产品形式

    PBS, pH 6.5,Contains no stabilizers or preservatives

    纯度

    >95%, Determined by SDS-PAGE

    聚合

    <5%, Determined by SEC

    无菌处理

    0.2 µm filtration

    纯化方式

    Protein G

    RRID

    AB_10949073

    分子量

    150 kDa

    小鼠病原检测

    Ectromelia/Mousepox Virus: Negative

    Hantavirus: Negative

    K Virus: Negative

    Lactate Dehydrogenase-Elevating Virus: Negative

    Lymphocytic Choriomeningitis virus: Negative

    Mouse Adenovirus: Negative

    Mouse Cytomegalovirus: Negative

    Mouse Hepatitis Virus: Negative

    Mouse Minute Virus: Negative

    Mouse Norovirus: Negative

    Mouse Parvovirus: Negative

    Mouse Rotavirus: Negative

    Mycoplasma Pulmonis: Negative

    Pneumonia Virus of Mice: Negative

    Polyoma Virus: Negative

    Reovirus Screen: Negative

    Sendai Virus: Negative

    Theiler’s Murine Encephalomyelitis: Negative

    保存条件

    抗体原液保存在4°C,不能冷冻保存。

    推荐同型对照

    InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin(货号BP0090)

    推荐抗体稀释液

    InVivoPure pH 6.5 Dilution Buffer(货号IP0065)

     

    为什么选择InVivoPlus抗体?

    InVivoPlus级别的产品内毒素含量更低,经过多种实验验证,更适合用于体内实验研究

    BioXcell热销产品推荐--InVivoPlus anti-mouse PD-L1 (B7-H1)


    该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:



    应用

    文章

    体内PD-L1阻断

    (in vivo PD-L1 blockade)

    1. Grasselly, C., et al. (2018). 'The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent' Front Immunol 9: 2100.

    2. Stathopoulou, C., et al. (2018). 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells' Immunity 49(2): 247-263 e247.

    3. Kim, J., et al. (2015). 'Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help' Nat Commun 6: 7994.

    体内PD-L1阻断,流式细胞术

    (in vivo PD-L1 blockade, Flow Cytometry)

    1. Aloulou, M., et al. (2016). 'Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells' Nat Commun 7: 10579.

    2. Ngiow, S. F., et al. (2015). 'A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1' Cancer Res 75(18): 3800-3811.

    3. Rutigliano, J. A., et al. (2014). 'Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells' J Virol 88(3): 1636-1651.

    体内PD-L1阻断,免疫荧光

    (in vivo PD-L1 blockade, Immunofluorescence)

    1.Willimsky, G., et al. (2013). 'Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance' J Clin Invest 123(3): 1032-1043.

    免疫组织化学(冷冻切片),免疫荧光

    (Immunohistochemistry (frozen), Immunofluorescence)

    1.Riella, L. V., et al. (2011). 'Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts' Am J Transplant 11(4): 832-840.



     

    BioXcell热销产品推荐--InVivoPlus anti-mouse PD-L1 (B7-H1) 

    更多产品详情请咨询 BioXcell 中国授权代理——欣博盛生物

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