Neuregulin-1 Type I-β2b Extracellular Domain (human, recombinant; aa 20-238)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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Neuregulin-1 Type I-β2b Extracellular Domain (human, recombinant; aa 20-238)

品牌：Cayman

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说明书

折扣/货期

货号：32094-1 mg	规格：1 mg	目录价：￥34866
货号：32094-100 µg	规格：100 µg	目录价：￥5364

产品详情

产品名称:

Neuregulin-1 Type I-β2b Extracellular Domain (human, recombinant; aa 20-238)

别名:

产品描述:

Neuregulin-1 type I-β2b is a trophic factor and member of the neuregulin-1 family of growth factors, which comprises greater than 30 isoforms grouped into types I through VI based on their N-terminal region, which is generated by alternative splicing of NRG1.{69199} It is composed of a type I N-terminal domain, an immunoglobulin-like (Ig-like) domain, a glycosylated domain, an EGF-like domain, a linker region that contains a proteolytic cleavage site to release the mature protein, a transmembrane domain, and a cytoplasmic tail.{69199,69200} The type I-β2b splice variant of Nrg1 is mainly expressed in the brain and stomach but is also expressed at low levels in most tissues.{69200} Neuregulin-1 signaling is mediated by homodimers of HER4 and the heterodimers HER2-HER3, HER2-HER4, HER3-HER4, and EGFR-HER4.{69199} The cytoplasmic domain of neuregulin-1 type I-β2b induces apoptosis in breast cancer cells, and the mature protein induces apoptosis in fibroblasts in vitro.{69201,69200} This protein consists of 230 amino acids and has a calculated molecular weight of 25.3 kDa. By SDS-PAGE, the apparent molecular mass of the protein is approximately 45 kDa due to glycosylation.

宿主来源:

HEK293 cells

保存温度:

-80

运输温度:

-80

产品形式:

Lyophilized from sterile PBS, pH 7.4

有效期:

365

纯度:

≥95% estimated by SDS-PAGE