九游会j9网站首页,j9九游会首页登录,j9九游会ag真人官网

深圳九游会j9网站首页有限公司 a1

MR1/β2-Microglobulin Complex (human, recombinant)
货号：30585 规格：20 µg 目录价：￥7840
产品详情
产品名称:
MR1/β2-Microglobulin Complex (human, recombinant)
别名:
Class I Histocompatibility Antigen-like Protein|Major Histocompatibility Complex Class I-related Gene Protein|MHC Class I-related Gene Protein|β2M|β2-Microprotein
产品描述:
MHC class I-related gene protein (MR1) is a non-polymorphic MHC class Ib antigen-presenting cell surface molecule that is required for T cell receptor-mediated activation of mucosal-associated invariant T (MAIT) cells.{60473,60472} MR1 is composed of α1 and α2 domains, which form an antigen-binding pocket, and an α3 domain that interacts with β2-microglobulin, the light chain component of MHC class I molecules that facilitates complex transport to the cell surface and antigen presentation to cytotoxic T cells.{60472,45065} Upon binding of a microbial antigen, MR1 undergoes a conformational change in the endoplasmic reticulum and translocates to the cell surface with β2-microglobulin where it induces MAIT cell activation via an interaction with the MAIT cell T cell receptor and activates various immunomodulatory effects, including cytokine release, initiation of adaptive immune responses, and promotion of tissue repair.{45938,60474} The antigen-binding domain of MR1 binds to vitamin B metabolites, including metabolites of vitamin B2, also known as riboflavin, and vitamin B9 (folic acid; Item No. 20515).{45742} MHC class I-associated β2-microglobulin exhibits equilibrium exchange with circulating soluble β2-microglobulin and serum levels of β2-microglobulin are increased in patients with cancer, renal failure, systemic amyloidosis, or various autoimmune diseases, including multiple sclerosis.{45065,45066,45067,45064}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
在线留言
咨询类型
联系人
*
联系方式
*
单位名称
*
咨询内容
*
九游会j9网站首页