官网链接
折扣/货期| 货号：38215 | 规格：400 µl | 目录价：￥5698 |
产品详情
产品名称:
MR1 Immunoaffinity Sorbent
别名:
Class I Histocompatibility Antigen-like Protein|Major Histocompatibility Complex Class I-related Gene Protein|MHC Class I-related Gene Protein
产品描述:
Major histocompatibility complex (MHC) class I-related gene protein (MR1) is a non-polymorphic MHC class Ib antigen-presenting cell surface molecule that is required for T cell receptor-mediated activation of mucosal-associated invariant T (MAIT) cells.{60473,60472} It is composed of α1 and α2 domains, which form an antigen-binding pocket, and an α3 domain that interacts with β2-microglobulin.{60472} MR1 mRNA is ubiquitously expressed and, following translation, MR1 protein is localized to the endoplasmic reticulum in a partially folded state. Upon binding of a riboflavin-derived microbial antigen, MR1 undergoes a conformational change and translocates to the cell surface where it induces MAIT cell activation via an interaction with the MAIT cell T cell receptor and activates various immunomodulatory effects, including cytokine release, initiation of adaptive immune responses, and promotion of tissue repair.{60474} Cayman's MR1 Immunoaffinity Sorbent is designed for immunoprecipitation (IP) of MR1 protein from biological samples. This is an effective way to concentrate MR1 protein for subsequent detection by a different MR1 antibody by immunoprecipitation (IP) (LC/MS certified) and Western blot (WB). The MR1 affinity sorbent consists of Cayman's MR1 Monoclonal Antibody (Clone 2H7) (Item No. 34257) coupled to CNBr-activated Sepharose 4B.
宿主来源:
Mouse
实验应用:
IP, WB, LC-MS
同种型:
IgG1
免疫原:
Recombinant human MR1 (aa 22-292) protein
克隆号:
2H7
保存温度:
4
运输温度:
4
产品形式:
400 µl of CNBr-activated Sepharose 4B coupled to a human MR1 monoclonal antibody (Clone 2H7) (Item No. 34257)
有效期:
365
您可能感兴趣的产品
Puromycin Dihydrochloride Antibiotic Solution
货号：MIR 5940
Hygromycin B Antibiotic Solution
货号：MIR 5930
G418 Sulfate Antibiotic Solution
货号：MIR 5920
DAPI/Antifade
货号：D-0902-500-DA
TissueFISH Pretreatment Kit
货号：D-0905-025-TF
DNA High-Binding Plates
货号：AKR-5184
DNA Coating Solution
货号：AKR-5183
DNA Coating Solution, with 96-well Plate
货号：AKR-5182
促销活动
