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Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated
品牌：EpiCypher
货号：16-0323 规格：100 µg 目录价：￥5100
产品详情
产品名称:
Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated
产品描述:
Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3.3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.3-P84243; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA. Histone H3.3 is a non-allelic replacement found in regions of high chromatin turnover outside of S-phase (e.g. at actively transcribed genes). The substitution of M for K at position 27 is a dominant negative inhibitor of the EZH2 methyltransferase complex PRC2 and is associated with pediatric brain cancer (DIPG) [1]. The nucleosome is the basic subunit of chromatin. The 147 bp 601 sequence, identified by Lowary and Widom [2], has high affinity for histone octamers and is useful for nucleosome assembly. The DNA contains a 5’ biotin-TEG group.
保存温度:
Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
运输温度:
Dry ice.
产品形式:
H3.3K27M Mononucleosomes (54.6 µg protein weight, 100.0 µg DNA + protein) in 90.9 µL 10 mM Tris HCl pH 7.5, 25 mM NaCl, 1 mM EDTA, 2 mM DTT, 20% glycerol. Molarity = 5.5 μM. MW = 199,844 Da.
产地:
美国
生产商:
EpiCypher
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