官网链接
折扣/货期| 货号：33743 | 规格：10 µg | 目录价：￥7632 |
产品详情
产品名称:
MERTK Extracellular Domain (human, recombinant)
别名:
c-Mer|MER|Proto-oncogene c-Mer|Receptor Tyrosine Kinase MerTK|RP38|Tyrosine-protein Kinase Mer
产品描述:
MERTK is a TAM family receptor tyrosine kinase with roles in macrophage activation, apoptotic cell engulfment, and platelet aggregation.{60949,60950} It is composed of an extracellular domain, which contains two immunoglobulin-like (Ig-like) domains and two FNIII domains, and an intracellular tyrosine kinase domain.{60949} MERTK is expressed at low levels in the brain in oligodendrocytes, astrocytes, and microglia, as well as in the heart and skeletal muscle, and at high levels in the ovary, prostate, testis, lung, retina, and kidney. It is also expressed in platelets, megakaryocytes, dendritic cells, natural killer (NK) cells, monocytes, and macrophages.{60951} Membrane-bound MERTK can be cleaved by a metalloproteinase to release the extracellular domain as a soluble form of MERTK (sMer), which binds the MERTK activating ligand Gas6 to block Gas6-mediated MERTK activation, leading to defective macrophage-mediated engulfment of apoptotic cells and decreased platelet aggregation.{60950} Mutations in MERTK are associated with severe disease in patients with inherited retinal disease.{60952} Cayman’s MERTK Extracellular Domain (human, recombinant) can be used for enzyme activity assay applications.
保存温度:
-80
运输温度:
-80
产品形式:
40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 0.04% Tween 20, 20% glycerol, and 1.6 mM glutathione
有效期:
180
纯度:
≥90% estimated by SDS-PAGE
您可能感兴趣的产品
Human SLD5 protein, His tag
货号：GTX69573-pro
Human PSMG3 protein, His tag
货号：GTX68801-pro
Human ARL6 protein, His tag
货号：GTX68797-pro
Human HDHD2 protein, His tag
货号：GTX68796-pro
Human TATDN1 protein, His tag
货号：GTX68792-pro
Human ATG10 protein, His tag
货号：GTX68788-pro
Human DYNLRB1 protein, His tag
货号：GTX68785-pro
Human AMMECR1L protein, His tag
货号：GTX68782-pro
促销活动
相关产品推荐
