Melatonin Receptor Type 1A (human recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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Melatonin Receptor Type 1A (human recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：24731

规格：10 µg

目录价：￥21364

产品详情

产品名称:

Melatonin Receptor Type 1A (human recombinant)

别名:

MT1

产品描述:

Melatonin receptor type 1A (MT1) (human recombinant) contains amino acids corresponding to the full length, wild-type human MT1 receptor, as well as N-terminal histidine and streptavidin tags with a TEV protease cleavage site. The MT1 receptor is encoded by the MTNR1A gene and is a G protein-coupled receptor expressed on post-synaptic terminals in the suprachiasmic nucleus (SCN) and hypothalamus.{36621} It is activated by melatonin and signals through Gi and Gq proteins. Based on MT1 and MT2 receptor knockout mouse studies, the MT1 receptor is involved in decreasing neuronal firing in the SCN and inhibits prolactin secretion in the pituitary gland. MT1 receptor activation inhibits proliferation of hormone-refractory 22Rv1 prostate cancer cells in vitro.{36622} Polymorphisms in the MTNR1A gene are associated with a higher risk of oral cancer and hepatocellular carcinoma and of developing distant metastases{36623,36624}

保存温度:

-80

运输温度:

-80

产品形式:

25mM disodium phosphate, pH 8.0, 150 mM sodium chloride, 0.86%/0.18% sarkosyl/CHS

有效期:

730

纯度:

≥90% estimated by SDS-PAGE

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