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折扣/货期| 货号：39726-1 mg | 规格：1 mg | 目录价：￥3906 |
| 货号：39726-5 mg | 规格：5 mg | 目录价：￥13384 |
| 货号：39726-500 µg | 规格：500 µg | 目录价：￥2058 |
产品详情
产品名称:
M40 (trifluoroacetate salt)
别名:
Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide
产品描述:
M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).{57419,67613} It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM).{57419} M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2 receptor (EC50 = 16.2 nM) and inhibits forskolin-induced cAMP accumulation in RIN-m5F pancreatic β-cells when used at concentrations of 10 or 100 nM.{57419,67613} In vivo, M40 (9.36 nmol/animal, i.c.v.) reverses galanin-induced inhibition of scopolamine-induced hippocampal acetylcholine (ACh) release in conscious rats.{67613} M40 reduces galanin-induced increases in food intake in rats. It improves cardiac function and decreases cardiac fibrosis in a rat model of heart failure induced by sustained coronary artery ligation when administered at a dose of 30 nmol/kg.{67614} M40 (20 µg/animal) increases the intromission frequency and ejaculation latency in sexually sluggish male mice.{67615}
保存温度:
-20
运输温度:
-20
预期分子量:
1981.3
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C94H145N23O24 • XCF3COOH
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