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LAIR-2 (human, recombinant)
品牌：Cayman
货号：32019-1 mg 规格：1 mg 目录价：￥38358
货号：32019-100 µg 规格：100 µg 目录价：￥5904
产品详情
产品名称:
LAIR-2 (human, recombinant)
别名:
CD306|Leukocyte-associated Immunoglobulin-like Receptor 2
产品描述:
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) is a soluble homolog of the membrane-bound inhibitory immune receptor LAIR-1.{56048} LAIR-2, which is comprised of a single immunoglobulin-like domain, binds to collagen and inhibits the LAIR-1/collagen interaction and subsequent activation of immunocytes.{56048,56047} It is produced by human peripheral blood mononuclear cells (PBMCs), monocytic and T cell lines, and activated CD4+ T cells.{56047,56050} LAIR-2 fused to the Fc region of human IgG1 inhibits collagen-induced platelet aggregation, adhesion of platelets to collagen-coated coverslips, and binding of collagen to von Willebrand factor (VWF) and glycoprotein VI (GpVI).{56049} Elevated levels of LAIR-2 have been found in the urine of pregnant women, the synovial fluid of patients with rheumatoid arthritis, and sera from patients with autoimmune thyroid diseases.{56047,56048} Cayman's LAIR-2 (human, recombinant) protein can be used for binding assay applications. This protein consists of 131 amino acids, has a calculated molecular weight of 14.1 kDa, and a predicted N-terminus of Gln22 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 22 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 50 mM Tris with 0.7 M sodium chloride, pH 8.0
有效期:
365
纯度:
≥93% estimated by SDS-PAGE
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