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    IL-38 (human) (rec.) (His)
    品牌：Adipogen
    货号：AG-40A-0191-C050 规格：50 ug 目录价：￥7080
    产品详情
    产品名称:
    IL-38 (human) (rec.) (His)
    别名:
    Interleukin-38; Interleukin-1 Family Member 10 theta; IL-1F10; FIL1 theta; FKSG75; IL-1HY2; IL1-theta; Interleukin-1 HY2; Interleukin-1 Receptor Antagonist FKSG75
    产品描述:
    IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
    宿主来源:
    E. coli
    保存温度:
    -20°C
    运输温度:
    BLUE ICE
    预期分子量:
    ~18kDa (SDS-PAGE)
    产品形式:
    solid
    存储溶液:
    Lyophilized from 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
    有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C.
    产地:
    瑞士
    纯度:
    >95% (SDS-PAGE)
    内毒素水平:
    <1EU/µg purified protein (LAL test; Lonza).
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