IL-36Ra (human) Matched Pair Detection Set-抗体对-ELISA_抗体_蛋白_核苷酸

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IL-36Ra (human) Matched Pair Detection Set

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-46B-0006-KI01

规格：1 Set

目录价：￥7800

产品详情

产品名称:

IL-36Ra (human) Matched Pair Detection Set

别名:

Interleukin-36 Receptor Antagonist Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1delta Interleukin-1delta; Interleukin-1 Homolog 3; Interleukin-1-like Protein 1

产品描述:

IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

靶标/特异性:

Detects human IL-36Ra.

保存温度:

-20°C

运输温度:

BLUE ICE

有效期:

Stable for at least 1 year after receipt when stored at -20°C.

产地:

瑞士

灵敏度:

0.5ng/ml