官网链接
折扣/货期| 货号：AG-40B-0100-C010 | 规格：10 ug | 目录价：￥2280 |
产品详情
产品名称:
IL-36gamma (aa 13-164) (mouse) (rec.) (untagged)
别名:
Interleukin-36gamma; Interleukin-1 Family Member 9; IL-1F9
产品描述:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.
宿主来源:
E. coli
产品浓度:
0.1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~17kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS + 0.5% Trehalose.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Induces secretion of IL-6 in BMDCs.
内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
上一个:IL-36beta (aa 31-183) (mouse) (rec.) (untagged)
下一个:IL-36gamma (aa 13-164) (mouse) (rec.) (FLAG)
您可能感兴趣的产品
Human IL1F5 protein, His tag
货号：GTX68383-pro
Human VEGF165 protein, His tag
货号：GTX67937-pro
Rat IL6 protein, His tag (active)
货号：GTX67073-pro
Human IL6 protein, His tag (active)
货号：GTX67071-pro
Human IL2 protein (active)
货号：GTX67060-pro
Feline IL2 protein, His tag (active)
货号：GTX66898-pro
Human IL1 Receptor 1 protein, human IgG1 Fc tag (active)
货号：GTX65662-pro
Human IL1F10 protein, His tag
货号：GTX57238-pro
促销活动
精品推荐
相关产品推荐
IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12002-C010
IL-4 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12004-C010
IL-6 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12006-C050
IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12010-C010
IL-21 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12021-C050
IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12021R-C025
