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折扣/货期| 货号：AG-40B-0098-C010 | 规格：10 ug | 目录价：￥2280 |
产品详情
产品名称:
IL-36alpha (aa 8-160) (mouse) (rec.) (untagged)
别名:
Interleukin-36alpha; Interleukin-1 Family Member 6; IL-1F6; FIL1epsilon; Interleukin-1epsilon; Interleukin-1 Homolog 1; IL-1H1
产品描述:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported.
宿主来源:
E. coli
产品浓度:
0.1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~17kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Induces secretion of IL-6 in BMDCs at a concentration of 100ng - 1µg/ml.
内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
上一个:IL-36Ra (aa 2-156) (human) (rec.) (untagged) MultiPack
下一个:IL-36beta (aa 31-183) (mouse) (rec.) (untagged)
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