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    IL-35 (human):Fc (human) (rec.)
    品牌：Adipogen
    货号：CHI-HF-21035-C025 规格：25 ug 目录价：￥3360
    产品详情
    产品名称:
    IL-35 (human):Fc (human) (rec.)
    别名:
    Interleukin-35
    产品描述:
    Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.
    宿主来源:
    CHO cells
    保存温度:
    -20°C
    运输温度:
    BLUE ICE
    产品形式:
    solid
    存储溶液:
    Lyophilized from 0.2µm-filtered solution in PBS.
    有效期:
    Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    产地:
    瑞士
    纯度:
    >98% (SDS-PAGE)
    生物活性:
    Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.
    内毒素水平:
    <0.06EU/µg protein (LAL test; Lonza).
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