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折扣/货期| 货号：CHI-HF-20121-C010 | 规格：10 ug | 目录价：￥2940 |
产品详情
产品名称:
IL-21 (human) (rec.) (His)
别名:
Interleukin-21
产品描述:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naïve T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.
宿主来源:
HEK 293 cells
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~18kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Measured by a cell proliferation assay using human N1186 T cells. The ED50 for this effect is typically 10ng/mL, corresponding to a specific activity of 1x 105 units/mg
内毒素水平:
<0.01EU/µg protein (LAL test; Lonza).
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