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折扣/货期| 货号：AG-46B-0004-KI01 | 规格：1 Set | 目录价：￥7800 |
产品详情
产品名称:
IL-1alpha (mouse) Matched Pair Detection Set
别名:
Interleukin-1alpha
产品描述:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
靶标/特异性:
Detects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta.
保存温度:
-20°C
运输温度:
BLUE ICE
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
灵敏度:
10pg/ml
检测范围:
15.6 to 2000pg/ml
检测方法:
Sandwich
样本类型:
Cell Culture Supernatant
促销活动
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