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折扣/货期| 货号：CHI-HF-21115MBI-1 | 规格：1 Vial | 目录价：￥6020 |
产品详情
产品名称:
IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)
别名:
Interleukin-15
产品描述:
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines. Application: Useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IL-15Ralpha expressing cells within mixed cell populations.
宿主来源:
CHO cells
偶联:
Biotin
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
solid
存储溶液:
Lyophilized. In PBS and 0.09% sodium azide.
有效期:
Stable for at least 6 months after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
This mutant IL-15/Fc fusion protein specifically binds to the IL-15R, competitively inhibits IL-15-triggered cell proliferation, promotes transplant tolerance, does not activate the STAT-signaling pathway, and exerts a prolonged circulating half-life caused by the modified Fc domain.
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
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