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折扣/货期| 货号：GTX03561-pro | 规格：100μg | 目录价：￥6600 |
产品详情
产品名称:
Human PTPN12 protein, His tag and GST tag (active)
别名:
protein tyrosine phosphatase non-receptor type 12 , PTP-PEST , PTPG1
实验应用:
Functional Assay
克隆号:
偶联:
Unconjugated
产品浓度:
表达系统:
Baculovirus-Insect Cells
保存温度:
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
运输温度:
4°C
产品形式:
Lyophilized powder
存储溶液:
Batch dependent (please contact us for details)
产地:
美国
功能与背景:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
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