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折扣/货期| 货号：11081 | 规格：500 µg | 目录价：￥6720 |
产品详情
产品名称:
Histone H2B Type 1-A (human, recombinant)
别名:
H2BC1|HIST1H2BA|hTSH2B|TH2B|TSH2B.1
产品描述:
Human histone H2B type 1-A (hTSH2B) is a testis- and sperm-specific variant of the histone H2B protein that is encoded by H2BC1, previously known as HIST1H2BA.{53231,53236} hTSH2B shares 85% identity with human somatic H2B.1, with the majority of amino acid differences between hTSH2B and somatic H2B occurring at the N-terminal end of the protein.{53231} H2BC1 is expressed in testis, and protein levels of hTSH2B are elevated in early round spermatids, decreasing over the course of spermiogenesis, with hTSH2B present in approximately 20% of mature spermatozoa.{53231,53232} hTSH2B is enriched at promoter regions of genes important for sperm biology, capacitation, and fertilization and localizes to the basal nuclear area in mature spermatozoa.{53231,53233} When incubated in Xenopus egg extracts, hTSH2B-positive human sperm cells decondense more rapidly and have increased long nuclear axis lengths compared with hTSH2B-negative sperm cells.{53234} Mice lacking the genes encoding the murine homolog of hTSH2B (TH2B), as well as the histone variant TH2A (Th2a-/-Th2b-/- mice), are sterile and have spermatogenesis defects.{53235} Cayman's Histone H2B Type 1-A (human, recombinant) can be used for Western blot and ELISA applications.
保存温度:
-80
运输温度:
-80
产品形式:
A solution in water
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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