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折扣/货期| 货号：10009232 | 规格：50 µg | 目录价：￥9108 |
产品详情
产品名称:
HDAC3/NCOR2 (human, recombinant)
别名:
Histone Deacetylase 3/Nuclear Receptor Corepressor 2
产品描述:
Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. They are also involved in mediating other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.{14467} HDAC3 is a Class I HDAC which is related to the yeast HDAC Rpd3.{14468} It is primarily localized to the nucleus with ubiquitous distribution throughout human cell lines and tissues. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}
保存温度:
-80
运输温度:
-80
产品形式:
40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 250 mM imidazole, and 20% glycerol
有效期:
180
纯度:
≥90%
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