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GSK3β (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：33738

规格：10 µg

目录价：￥7236

产品详情

产品名称:

GSK3β (human, recombinant)

别名:

Glycogen Synthase Kinase 3β|GSK3B|Serine/threonine-protein Kinase GSK3B

产品描述:

Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.{60859,60860} It is composed of an N-terminal β-strand domain, a kinase domain, and a C-terminal α-helical domain.{60861} GSK3β is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria.{60860,60862} It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA, PKB, and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways.{60860} GSK3β is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder.{60862,60859} Cayman's GSK3β (human, recombinant) protein can be used for enzymatic activity assays.

宿主来源:

Insect cells

保存温度:

-80

运输温度:

-80

产品形式:

Active recombinant human GST-tagged, His-tagged GSK3β expressed in insect cells

有效期:

180

纯度:

≥90% estimated by SDS-PAGE