官网链接
折扣/货期| 货号：31037 | 规格：100 µg | 目录价：￥5376 |
产品详情
产品名称:
Glutaredoxin 1 (human, recombinant)
别名:
Glrx1|Grx1|Thioltransferase 1|TTF1
产品描述:
Glutaredoxin 1 (Grx1) is a thiol-disulfide oxidoreductase and member of the thioredoxin family encoded by GLRX1 with a role in the maintenance of cellular thiol redox homeostasis.{53968} It is ubiquitously expressed and localizes to the cytosol, nucleus, and mitochondrial intermembrane space. Grx1 is a dithiol Grx that contains two active site cysteine residues, which catalyze the deglutathionylation of protein disulfides and glutathionylated proteins to regulate redox signal transduction and repair oxidized proteins.{49701,53969,49702} Knockdown or overexpression of GLRX1 enhances or reduces, respectively, oxidative stress-induced apoptosis in HEK293T cells.{49703} Glrx1-/- mice have increased bronchoalveolar lavage fluid (BALF) macrophage infiltration and lung glutathionylated protein levels induced by cigarette smoke compared with wild-type mice.{49704} Grx1 levels are decreased in postmortem brain from patients with Parkinson's disease.{49702} Cayman's Glutaredoxin 1 (human, recombinant) can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris-HCl, pH 7.8, with 150 mM sodium chloride, 10% glycerol, 1 mM EDTA, and 0.1 mM DTT
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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