官网链接
折扣/货期| 货号：26695 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
GDP-L-Fucose Synthase (human, recombinant)
别名:
GDP-4-keto-6-deoxy-D-Mannose-3,5-Epimerase-4-Reductase|Protein FX|Red Cell NADP(H)-Binding Protein|Short-Chain Dehydrogenase/Reductase Family 4E Member 1|Tissue Specific Transplantation Antigen P35B|TSTA3
产品描述:
GDP-L-Fucose synthase, encoded by the gene TSTA3, is an NADP(H)-binding protein that catalyzes the final step in the synthesis of GDP-L-fucose from GDP-D-mannose.{42819,42820} It converts GDP-4-keto-6-deoxy-D-mannose to GDP-L-fucose via a two-step reaction consisting of epimerization followed by NADPH-dependent reduction. GDP-L-Fucose synthase exists as a homodimer and is comprised of an N-terminal NADPH-binding domain and a C-terminal substrate-binding domain. TSTA3-/- mice exhibit increases in colonic inflammation, dysplasia, and epithelial permeability, which are reversed following addition of fucose to the diet.{42821} These mice also exhibit alterations in gut microflora and increased bacterial burden in colon transluminal tissue and feces when fed a normal diet versus a fucose-supplemented diet, and the colonic effects of TSTA3 deletion can be reversed following administration of antibiotics. GDP-L-Fucose synthase has been identified as an autoantigen that can be recognized by CD4+ T cells derived from patients with multiple sclerosis.{42822} Expression of GDP-L-fucose synthase in primary tumor tissue samples from patients with esophageal squamous cell carcinoma (ESCC) positively correlates with increased clinical stage, lymph node metastasis, and poor prognosis.{42823}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
您可能感兴趣的产品
Human Aldolase C protein
货号：GTX67212-pro
Human Sorbitol Dehydrogenase protein (active)
货号：GTX67160-pro
Human Fumarate hydratase protein (active)
货号：GTX66998-pro
beta Galactosidase protein
货号：GTX04676-pro
Human Lysozyme protein (active)
货号：GTX03701-pro
Human Flavin reductase protein
货号：GTX67254-pro
Human Aspartoacylase protein
货号：GTX67242-pro
Human Aldolase C protein (active)
货号：GTX66923-pro
促销活动
