官网链接
折扣/货期| 货号：29611 | 规格：50 µg | 目录价：￥7238 |
产品详情
产品名称:
FSP1 (human, recombinant)
别名:
AIFM2|Apoptosis-inducing Factor Homologous Mitochondrion-associated Inducer of Death|Apoptosis-inducing Factor Mitochondria-associated 2|Ferroptosis Suppressor Protein 1|p53-Responsive Gene 3 Protein|PRG3
产品描述:
Ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), is a flavoprotein and NAD(P)H-dependent oxidoreductase that inhibits ferroptosis in a glutathione peroxidase 4- and glutathione-independent manner.{50700,50699,45864} It is encoded by AIFM2 in humans and is composed of a short N-terminal hydrophobic region followed by a flavin adenine dinucleotide-dependent oxidoreductase domain.{50699} FSP1 localizes to the plasma membrane in a myristoylation-dependent manner, where it reduces coenzyme Q10 (CoQ10; Item No. 11506) to CoQ10H2. Reduced CoQ10 functions as a radical-trapping antioxidant and inhibits lipid peroxidation. AIFM2 expression positively correlates with resistance to glutathione peroxidase 4 (GPX4) inhibitors, including (1S,3R)-RSL3 (Item No. 19288), ML-210 (Item No. 23282), and ML-162 (Item No. 20455) in cancer cell lines. Withdrawal of the ferroptosis inhibitor ferrostatin-1 (Item No. 17729) reduces tumor growth in an Fsp1/Gpx4 double knockout, but not a Gpx4 single knockout, H460 lung cancer mouse xenograft model, indicating that FSP1 confers resistance to ferroptotic cell death. Cayman's FSP1 (human, recombinant) protein can be used for enzyme assay applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM potassium phosphate, pH 7.8, with 200 mM sodium chloride, 10% glycerol, and 0.1 mM TCEP
有效期:
365
纯度:
≥70% estimated by SDS-PAGE
您可能感兴趣的产品
Human Aldolase C protein
货号：GTX67212-pro
Human Sorbitol Dehydrogenase protein (active)
货号：GTX67160-pro
Human Fumarate hydratase protein (active)
货号：GTX66998-pro
beta Galactosidase protein
货号：GTX04676-pro
Human Lysozyme protein (active)
货号：GTX03701-pro
Human Flavin reductase protein
货号：GTX67254-pro
Human Aspartoacylase protein
货号：GTX67242-pro
Human Aldolase C protein (active)
货号：GTX66923-pro
促销活动
