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折扣/货期| 货号：AG-40A-0091Y-C010 | 规格：10 ug | 目录价：￥1440 |
| 货号：AG-40A-0091Y-C050 | 规格：50 ug | 目录价：￥3960 |
产品详情
产品名称:
FGF-21 (human) (rec.)
别名:
Fibroblast Growth Factor 21
产品描述:
The fibroblast growth factor (FGF) family is a group of multifunctional signaling molecules that have a wide variety of functions. The family comprises of 22 related proteins, each grouped into subfamilies which are based on genetic and functional similarity. FGF21 is expressed in several tissues such as liver (main site), muscles, adipocytes, pancreas, and brain where it passes the blood-brain barrier. FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. Its activity requires the presence of the FGFR1 and beta-klotho. FGF21 mediates the adaptive starvation response to induce ketogenesis, gluconeogenesis, lipolysis, and lipid beta-oxidation. FGF21 plays also a key role in cardiac remodeling with the heart expressing fibroblast growth factor receptor 1 (FGFR1), beta-klotho, as well as FGF21. In muscle, FGF21 expression in skeletal muscles is due to mitochondrial dysfunction and ER stress.
宿主来源:
HEK 293 cells
产品浓度:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~22kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
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