货号:14199 | 规格:100 µg | 目录价:¥5544 |
产品详情
产品名称:
FEN1 (human, recombinant)
别名:
Flap Endonuclease 1|hFEN1
产品描述:
Flap endonuclease 1 (FEN1), a RAD2 Class II nuclease, plays a crucial role in DNA repair, replication, and genomic stability.{28481} FEN1 removes the 5'-unannealed flap during Okazaki fragment processing in lagging strand DNA synthesis.{28483} Removal of the DNA flap is also critical in long-patch base excision repair and regulation of recombination.{22126} In yeast, FEN1 mutants display sensitivity to UV irradiation, deficient chromosome segregation, and cell cycle arrest in S phase.{28482} Furthermore, haploinsufficiency of FEN1 in mice leads to rapid tumor progression.{28482} FEN1 is overexpressed in many forms of cancer, including lung, gastric, prostate, pancreatic, brain, and breast.{22126}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, containing 1 mM DTT and 10% glycerol
有效期:
365
纯度:
≥85% estimated by SDS-PAGE
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