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折扣/货期| 货号：25828 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
Fatty Acid Desaturase 2 (human recombinant)
别名:
Acyl-CoA 6-Desaturase|D6D|DES6|EC 1.14.19.3|FADS2|FADSD6|Linoleoyl-CoA Desaturase (Δ6-Desaturase)-Like 2|LLCDL2|SLL0262|TU13|Δ6 Fatty Acid Desaturase
产品描述:
Fatty acid desaturase 2 (FADS2), also known as Δ6-desaturase, is a 444-amino acid transmembrane protein encoded by FADS2.{49056} This product is the N-terminal cytoplasmic domain of FADS2, corresponding to residues 2-131 of the full-length sequence. It catalyzes the rate-limiting step in the conversion of the ω-6 and ω-3 precursors linoleic acid (Item Nos. 90150 | 21909) and α-linolenic acid (Item No. 90210) to their respective long-chain polyunsaturated fatty acids (LC-PUFAs), inserting a cis double bond at position 6 of the fatty acid chain to convert linoleic acid to γ-linolenic acid (Item No. 90220) and α-linolenic acid to stearidonic acid (Item No. 90320), respectively. Following secondary desaturation by FADS1 (Item No. 25827) and chain elongation, FADS2 catalyzes desaturation of 24-carbon LC-PUFA intermediates. FADS2 also catalyzes the desaturation of palmitic acid (Item No. 10006627) to sapienic acid in human sebaceous glands and in various cancer cell lines that express FADS2.{45162,43766} Hepatic FADS2 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH).{43213} FADS2 knockout (fads2-/-) mice are infertile, resistant to obesity, and have altered subcellular membrane diacylglycerol composition which leads to dysregulated post-translational processing of SREBP1c, a key transcription factor in the regulation of lipid metabolism.{45163}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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