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    EPI-X4 (trifluoroacetate salt)
    品牌：Cayman
    货号：37912-1 mg 规格：1 mg 目录价：￥406
    货号：37912-10 mg 规格：10 mg 目录价：￥2240
    货号：37912-25 mg 规格：25 mg 目录价：￥4564
    货号：37912-5 mg 规格：5 mg 目录价：￥1526
    产品详情
    产品名称:
    EPI-X4 (trifluoroacetate salt)
    别名:
    Endogenous Peptide Inhibitor of CXCR4
    产品描述:
    EPI-X4 is an endogenous peptide fragment corresponding to amino acids 408-423 of human serum albumin and an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4).{51524} It inhibits calcium mobilization and receptor internalization induced by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells expressing CXCR4 when used at concentrations ranging from 0.8 to 1,000 µM. EPI-X4 inhibits CXCL12-induced migration of Jurkat T cells and human CD34+ hematopoietic stem cells. In vivo, EPI-X4 (16 µmol/kg) reduces Cxcr4-dependent inflammatory cell airway infiltration in a mouse model of acute allergic airway hypereosinophilia. Urinary levels of EPI-X4 are increased and inversely correlated with glomerular filtration rate (GFR) in patients with chronic kidney disease.
    保存温度:
    -20
    运输温度:
    -20
    预期分子量:
    1830.2
    产品形式:
    A solid
    有效期:
    1460
    纯度:
    ≥98%
    分子式:
    C84H144N22O23 • XCF3COOH
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