官网链接
折扣/货期| 货号：601390 | 规格：96 wells | 目录价：￥6496 |
产品详情
产品名称:
EP4 Receptor (human) Reporter Assay Kit
别名:
PGE2 Receptor 4|Prostaglandin E2 Receptor 4
产品描述:
Prostaglandin E2 (PGE2) is one of the most important biologically active prostanoids which exerts its actions mainly by binding to four distinct E-type prostanoid receptors: EP1, EP2, EP3, and EP4. These four G protein-coupled receptors (GPCRs) exhibit differences in signal transduction mechanisms, tissue localization, and regulation of expression. EP4 receptors are highly expressed in the intestine, but are found in lower levels in the lung, kidney, thymus, uterus, and brain. The receptors are primarily coupled to Gs to stimulate the cAMP second messenger signal transduction pathway. EP4 receptors play important roles in relaxation of smooth muscle, gastric acid secretion, intestinal epithelial transportation, adrenal aldosterone secretion, uterine functions, bone formation, bone resorption, immunity, and inflammation. They have been suggested to involve in colorectal carcinogenesis, neuroprotection in excitotoxic brain injury, and cardiac hypertrophy. The diverse effects of PGE2 via EP4 receptors point to the need to identify novel agonists, antagonists, and modulators, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases.
保存温度:
-20
运输温度:
-20
有效期:
365
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