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折扣/货期| 货号：38258 | 规格：100 µg | 目录价：￥7126 |
产品详情
产品名称:
Citrullinated Histone H4 (human, recombinant; His-tagged)
产品描述:
Histone H4 is one of four core histone proteins that is involved in the organization of DNA into chromatin.{18136} Histones are subject to a variety of post-translational modifications (PTMs), such as methylation, acetylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Histone H4 can be citrullinated at the arginine residue at position 3 (H4R3) by peptidyl arginine deiminase 4 (PAD4; Item No. 10500).{46198} Citrullination of H4R3 increases in U2OS cells following induction of DNA damage by adriamycin (doxorubicin; Item No. 15007) and is localized near fragmented nuclei.{46406} H4R3 citrullination is associated with smaller tumor size and inversely associated with p53 levels in tumor tissue samples derived from patients with non-small cell lung cancer (NSCLC). Citrullinated histone H4 is present in neutrophil extracellular traps (NETs) generated by stimulation of granulocytes with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and can be recognized by autoantibodies present in the serum of patients with rheumatoid arthritis.{46407} This product contains purified histone H4 (human, recombinant; His-tagged) (Item No. 38257) that has been modified with PAD4, which is subsequently depleted by affinity chromatography.
保存温度:
-80
运输温度:
-80
产品形式:
A solution in water
有效期:
365
纯度:
≥80% estimated by SDS-PAGE
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