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折扣/货期| 货号：25107 | 规格：100 µg | 目录价：￥7630 |
产品详情
产品名称:
Citrullinated GRP78 (human recombinant)
别名:
BiP|Endoplasmic Reticulum Lumenal Ca2+-Binding Protein GRP78|Glucose-Related Protein 78|Heat Shock Protein 5 (70 kDa)|Hsp5 (70 kDa)|Immunoglobulin Heavy Chain-Binding Protein
产品描述:
Glucose-regulated protein 78 kDa (GRP78) is a molecular chaperone that is ubiquitously expressed in the endoplasmic reticulum of mammalian cells.{36130,36131,36132} GRP78 can be citrullinated at its 27 arginine residues by protein deiminases (PADs).{37332} The accumulation of citrullinated proteins in vivo leads to the production of anti-citrullinated protein antibodies (ACPAs) which perpetuate the inflammatory process.{32067} In vitro, ACPAs bind to citrullinated GRP78 expressed on the cell surface of peripheral blood mononuclear cells PMBCs and U937 cells leading to the production of TNF-α.{37330,37331} In a mouse model of collagen-induced arthritis (CIA), anti-citrullinated GRP78 antibodies are found in the serum.{37332} Pre-immunization with citrullinated GRP78 prior to CIA induction shortens the time to joint inflammation and increases arthritis scores compared with non-citrullinated GRP78-immunized and non-immunized control mice. In autoimmune diseases such as rheumatoid arthritis, patient-derived serum contains higher levels of anti-citrullinated GRP78 antibodies than serum derived from patients with systemic lupus erythematosus and healthy controls.{37332}
保存温度:
-80
运输温度:
-80
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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