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折扣/货期| 货号：35645-1 mg | 规格：1 mg | 目录价：￥7518 |
| 货号：35645-5 mg | 规格：5 mg | 目录价：￥15288 |
| 货号：35645-500 µg | 规格：500 µg | 目录价：￥4704 |
产品详情
产品名称:
CGRP (8-37) (mouse, rat) (trifluoroacetate salt)
别名:
Calcitonin Gene-Related Peptide (8-37)|CGRP8-37|VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
产品描述:
Calcitonin gene-related protein (CGRP) (8-37) is a CGRP receptor antagonist.{41531} It corresponds to amino acids 8-37 of rodent α-CGRP (Item No. 24728), a neuropeptide. CGRP (8-37) selectively binds to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP3 (IC50s = 1 and 6.2 nM, respectively) over a complex of CRLR and RAMP2 (IC50 = 219 nM). It prevents CGRP-induced increases in heart rate and decreases in blood pressure in transgenic mice expressing rat CRLR in smooth muscle-containing tissues and sympathetic ganglia when administered at a dose of 2 µmol/kg.{69074} CGRP (8-37) also inhibits p-phenylquinone-induced writhing (ED50 = 6 µg/animal) and decreases body temperature in a dose-dependent manner in mice.{69075}
保存温度:
-20
运输温度:
-20
预期分子量:
3127.5
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C138H224N42O41 • XCF3COOH
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