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折扣/货期| 货号：11235 | 规格：100 µg | 目录价：￥4270 |
产品详情
产品名称:
CBX5 (human recombinant)
别名:
Antigen p25|Chromobox Protein Homolog 5|Heterochromatin Protein 1-α|HP1-α
产品描述:
The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1α (CBX5), HP1β (CBX1) and HP1γ (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain which connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX5 has been shown to recognize di- and tri-methylated lysine 9 on histone H3 (H3K9me2 and H3K9me3), with a preference for H3K9me3. Binding of CBX5 to methylated histones leads to gene silencing and heterochromatin formation.{20846,20874} H3K9 trimethylation by the methyltransferase SETDB1 creates a binding site for recruitment of CBX5, leading to chromatin condensation and gene silencing.{20845} The chromoshadow domain facilitates protein-protein interactions like homodimerization and recruitment of nuclear proteins involved in transcriptional regulation.{20843} The chromoshadow domain is also responsible for recruitment to sites of DNA damage, where CBX5 helps to reorganize chromatin as part of the DNA damage response system.{20844}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
有效期:
180
纯度:
≥95% estimated by SDS-PAGE
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