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折扣/货期| 货号：14492 | 规格：100 µg | 目录价：￥4858 |
产品详情
产品名称:
BRDT bromodomains 1 and 2 (human, recombinant)
别名:
BRD6|Bromodomain testis-specific protein|Cancer/testis antigen 9|CT9|RING3-like protein
产品描述:
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.{20313} Bromodomain testis-specific (BRDT) shares homology with the RING3 protein. The two bromodomains of BRDT recognize acetylated histone H4. Loss of BRDT leads to defects in spermatogenesis.{21052} In addition to testis specific expression, BRDT was found in approximately 20% of non-small cell lung cancers.{21053}
保存温度:
-80
运输温度:
-80
产品形式:
10 mM HEPES, pH 7.5, with 500 mM sodium chloride and 5% glycerol
有效期:
730
纯度:
≥85%
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