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折扣/货期| 货号：37408-1 mg | 规格：1 mg | 目录价：￥406 |
| 货号：37408-10 mg | 规格：10 mg | 目录价：￥1582 |
| 货号：37408-25 mg | 规格：25 mg | 目录价：￥2968 |
| 货号：37408-5 mg | 规格：5 mg | 目录价：￥1008 |
产品详情
产品名称:
Bradykinin (human, mouse, rat, bovine) (acetate)
别名:
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH|BK|RPPGFSPFR-OH
产品描述:
Bradykinin is an endogenous vasodilator that is also involved in inflammation.{5716,67125} It is formed from kininogen via cleavage of high molecular weight kininogen (HMWK) by kallikrein or prekallikrein in a Factor XIIa-dependent or -independent manner.{67126} Bradykinin binds to the bradykinin B2 receptor (IC50 = 0.54 nM in COS-7 cells expressing the human receptor) and acts as an agonist but does not bind the bradykinin B1 receptor (Ki = >10,000 nM in HEK293 cells expressing the human receptor).{49601,49599} It stimulates arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing the human bradykinin B2 receptor (EC50 = 0.7 nM).{49601} Bradykinin (100 nM) induces relaxation of isolated porcine coronary arterial rings precontracted with acetylcholine (ACh; Item No. 23829) or phorbol 12,13-dibutyrate (PDBu; Item No. 27785).{5716} It induces hyperalgesia in mice when administered at a dose of 1 µg/paw, an effect that can be reversed by the bradykinin B2 antagonist icatibant (HOE 140; Item No. 24083).{67125} Plasma levels of bradykinin are increased in patients during an acute attack of angioedema.{67127}
保存温度:
-20
运输温度:
-20
预期分子量:
1060.2
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
6846-03-3
分子式:
C50H73N15O11 • XC2H4O2
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