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Akt1 (human, recombinant)
品牌：Cayman
货号：10011209 规格：25 µg 目录价：￥5964
产品详情
产品名称:
Akt1 (human, recombinant)
别名:
PKBα|Protein Kinase Bα|RAC-PK-α|RAC-α Serine/threonine-protein Kinase
产品描述:
Akt1, also known as protein kinase Bα (PKBα), is a serine/threonine kinase belonging to the AGC kinase family and one of three Akt isoforms in mammals.{57326,59549} Akt kinases function downstream of activated tyrosine kinases and PI3K to regulate a variety of cellular processes, including cell size, growth, proliferation, and survival, as well as genome stability, glucose metabolism, and neovascularization.{59549} Akt1, like Akt2 and Akt3, is composed of an N-terminal pleckstrin homology (PH) domain, which binds to phosphatidylinositol-(3,4,5)-triphosphate (PIP3) and phosphatidylinositol-(3,4)-diphosphate (PIP2), a kinase domain, and a C-terminal regulatory hydrophobic motif. It is ubiquitously expressed and is the primary isoform in endothelial cells.{15560} Akt1 is activated via recruitment to the plasma membrane, which is mediated by the interaction of the Akt1 PH domain with PI3K-generated PIP3 and PIP2, and subsequent phosphorylation at threonine 308 and serine 473.{59549} Increased Akt1 kinase activity has been found in tumor tissue isolated from patients with prostate, breast, and ovarian cancers.{59550} Cayman’s Akt1 (human, recombinant) protein was phosphorylated by recombinant 3-phosphoinositide-dependent kinase 1 (PDK1) and can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride, 1 mM DTT, and 10% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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